Not unless you haul a lot of stuff. If you keep the spacer at 2.5in or less you won't substantially affect the axle bearing life, above that and things start to wear faster.
Just be cautious of the spacer you order, a lot of the spacers for the Dodge hubs (at least on the 9.25 axles) require a special splined acorn nut in order to bolt the spacer to the hub and still be able to get the rim on the spacer.
It's not a major issue, just be aware of the hole size on the spacer that will slide over the factory hub studs.
Also, if you end up getting splined acorn style lug nuts, only get the 6 spline, 5 spline lug nuts are cheap and crappy.