Well the transmission definitely won't bolt up to any newer engine. You'll have to find a hemi bell housing and even them you'll have to fab up some things. Your transmission is most likely a np435, I have the same in my 79 truck.
What I'd do is try to find a good running motor from a 94-2001 ram 1500. It's the 5.9 magnum engine, but it's basically a classic small block with a few upgrades. The 360s are stout motor when built up. Add a cam, intake, and maybe heads and you could be talking into the 400 hp range, possibly more torque.
Theoretically, you can put any engine you want in the truck. It's just a matter of money, time, and patience. Hell, I saw a guy at a car show with a 64' d100 with a viper engine in it. Really, it's just up to what you intend to do with the truck.