I owned a 2015 Ram 2500 6.4 Hemi for two years and 45,000 miles. We towed a 10,000 pound 5th wheel and it did a good job...not great, but good. Unloaded the 2500 got 16 mpg hiway and 12-14 in town. Power was set up different than a 1500, as it is often used for towing. It certainly is not faster off the line than a 1500 hemi, but it's designed to build torque for work, and it does a good job of that. The six speed tranny was very adequate for all around driving and towing. I would recommend it if someone was looking for a heavy duty truck.
While it did ride better that my previous f250 due to the coil springs, I absolutely HATED the ride. It is rough even on smooth roads, and jars you around on bad roads. Little ripples (tar strips) in the road constantly jars your spine. I made a left turn onto a bumpy road one day and my wife's head hit the passenger door window....boy, was she pissed. I could hardly ever drink coffee and drive it on anything but a super smooth hiway.
We permanently parked our 5th wheel in a private campground last June. By July 1st, I owned a 2017 Ram 1500. I couldn't wait to get ride of that battle wagon as a daily driver. For a daily driver the 2500 was terrible in my opinion. Others will disagree, but we couldn't believe the ride quality difference between the two trucks. When pulling the 5th wheel, it was really a nice truck to drive, but unloaded it was awful, as is any HD truck.
I could never recommend a 2500 to anyone as a daily driver. However, if you have a true need for a heavy duty truck, I would certainly recommend the Ram 2500 over the F250 or GM 2500.