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N0 difference at all. They all share same cab. I fit 4 tall people in mine. No issues whatsoever. Plenty of room. I’m 6’4. If my wife drives. She’s SHORT and I sit behind her it’s like a dang limo for meI don't know what difference there is in the cabs from the 1500 to the 2500 but in My 2500 I have a forward facing car seat on the passenger side and a rear facing seat behind the drivers seat. The rear facing seat leaves plenty of room for me to adjust the seat for leg room and I'm 6'0". My 3 year old can kick the back of the passenger seat but it is pushed all the way back and partly reclined. There seems to be the same if not more room than my wife's GMC Acadia.
Yep! You could put 3 car seats in the back of a crew cab and be just fine.
Now, make sure it's a crew cab. The quad cab will get a little tight. The rear doors are a little smaller, making it harder to get into with a kiddo. That was our impression, anyway.
Loads of room for two. They can fully extend legs. Careful though, they are messy as hell!
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I have a Durango with the captain seats second row, and my truck still has more room for the kiddos.