The Santa Cruz and Maverick might be a response to the Jeep Gladiator, which sold 40K units for the 2019 model year and 77K for 2020. The Gladiator looks like a truck, and further, like a truck Willys could have built in the 1940's, so it may have some retro appeal. The Santa Cruz seems twee; the Maverick looks more practical, plus Ford's hybrid system is among the better ones, so my guess is that it will be the better seller of the two. However, it probably won't take sales from the Gladiator, which seems to attract buyers in a higher income bracket. It may take them from the Ranger or the Colorado.
Not mentioned earlier was Ford's Explorer Sport Trac, made from 2001 to 2005 and 2007 to 2010. It was promoted as a mid-sized crew cab, but it was essentially an Explorer with a short bed. It was a poor seller during its last 4 years, which is commonly attributed to competition from the Chevy Avalanche and the Honda Ridgeline. But the Explorer sold poorly after it was redesigned for the 2006 model year, dropping below 6 figures for the 2008 through 2010 model years after selling more than 300,000 units annually for all but 4 years before 2006, so the design itself may be to blame.
Some pick-ups during the '60's were based on vans, notably the Dodge A100, the Chevy Greenbrier, and the VW microbus.
I've seen custom pick-ups made from passenger cars. One was a 1974 Cadillac in Michigan. Another was a 1958 Edsel at a swap meet in Belton, Texas (several were apparently converted from station wagons, and called “Edchero”). And a 1967 Charger at a Charger show in Boerne, Texas.
Shame on you. And thank you.