The Cummins 6.7 is a serious beast, and makes the truck do what it was designed to do... haul a load without any problems and without straining to do so. I am 25 months into my 2017 2500 Laramie, and love it. Unladen, it is "faster than a speeding ticket"; when pulling the four ton V-Lite (which weighs ~8,000 loaded), I keep checking to see if the trailer is still back there.
DEF is not a big deal... adding a 2.5-gallon jug ever so often... more when towing a lot, but not enough to be a problem by any means. The 6.7 is made for work... using it for pleasure is child's play.
As for oil and filter changes, follow what the "computer" tells you, or once annually, whichever is sooner. It will probably go 12,000-13,000 before the remaining percentage on the fuel and oil filters gets into the low 20% range. Again, it depends upon the type of driving you do. I have yet to find a sales rep who will tell anybody this. The guy who sold me mine referred me to the Service Manager, who verified this.