Anytime you jack a truck up and put bigger tires on it, you increase wear on parts not designed for the additional strain. That includes, but it not limited to, engine, transmission, rear end, u-joints, wheel bearings. For a 2500, most of that is negated by stroger parts to begine with, but it still plays hell with u-joints. 1500, you are going to feel the pain. And all of that does not even take into consideration the change to the speedometer. No big deal? Speed and engine rpm control transmission shifting, anti-lock brakes, lock up converter, etc.
Now, if you are willing to deal with it, carry on. As long as you understand it does not start and stop with the lift kit and big tires, it is just money. If you think that is where it starts and stops, well, a fool and his money are soon departed. Think of it as a learning experience.
Minimum after lift kit and tires : CV joint on rear driveshaft with solid heavy duty u-joints to make it last more than a year or a couple of hard launches. Spacers on transmission crossmember to try to lessen the angle between transmission and rear end a bit to help with the above. Ladder bars if you do not have a 4-link to keep the rear axil from walking forward and bending the u-bolts holding the axil to keep it from chewing up the tires against the wheel well and shoving the drive shaft into the output shaft of the transmission, destroying it...............gears, gears, gears. They will lesson the impact on the engine and transmission. A cool set of 35's will suck close to 50hp out of the engine. Gears.
body lifts are all good.
Also check your state laws. Some states require the bumper to be a certain number of inches from the road to keep from killing people in even a minor T-bone.
All that so you can be different. Just like everybody else.