So, I have 4 5.7 hemis.
A 11, 5.7 quad cab 4x4 6 sp, 3.55s
A 14 5.7, RCSB, supercharger, RWD, 8 speed, 3.92s
A 15, 5.7 8 speed, AWD Durango
A 16 5.7, 8 speed 4x4 quad cab 3.21s
So I have more than 1 data point.
My 11, 150k miles, original engine, updated coils, iridium plugs, avg 18 mpg highway. 15 in town
Real gas, drops ~2 mpg if it's ethanol.
My 14, 47k, supercharger avg 25 mpg highway, 20 in town. Ethanol numbers, I have not changed plugs nor run Real gas in this truck. Not really comparable.
My 15, AWD, 18 highway, 13 around town. It's a Durango RT, smaller lighter and not comparable to trucks. Real gas it will avg 23 highway and 16 around town
My 16, 5.7 Laramie with 8sp and 3.21. On 87 octane ethanol gas it will average 14 around town. On 89 real gas (non ethanol) it will easily get 16.5.
On trips, consistent 18 to 19 mpg even the occasional 20 if I not pushing low 90s.
I average driving 50K a year, in mileage. So fuel economy is a thought. Cost per mile is about the same as ethanol vs real gas due to the real gas premium, but fuel economy and power are different.