Also a consideration may be how much you are towing. Everyday, all day, you probably want the 3.92. If it's a daily driver that is rarely towing (my situation), better off with the 3.21.
Though if you're looking for more fun at a green light and don't care about the added fuel expense, go with the 3.92. I'd PREFER the 3.92. Though I'm sure my wife and my checking account would prefer the 3.21.
Bottom line for me is the 3.92 is harder to find in the truck I want, probably a 1500 Big Horn with MSRP around $65K. So will look for a 3.92, but probably end up with the 3.21.
For some perspective, I have a built Jeep for off road with aftermarket gears. It has 37" tires and 5.38 gears, a 4 speed trans (thanks Mopar). I probably wouldn't be unhappy with 5.13, but definitely want more low end torque. Though if it had 5.13 (more suitable for 35" tires), it wouldn't be worth it to pay for a re-gear to 5.38. It's just not enough of a difference. So stepping from one gear set to the next lowest, just doesn't make THAT much of a difference. If you drove the same vehicle with each gear set, I doubt many would be able to tell the difference. WIth the 8 speed, it's even less noticable.