Check to see if you have the sirius antenna on the roof. If you do not, you'll need one. If you do, it will be plug and play. You will be charged a $15 fee from sirius to change radio Id's on the truck if you already have a sirius account.
If the bottom of your mirror does not have the built in microphones, you likely are not already outfitted for uconnect. You will need to double check to make sure the radio you purchased even supports it, not all do, even though it has the uconnect button. You would the need a kit that came with the software and a stand alone microphone, or purchase the mirror with the built in microphone.