I'm on this like a BOSS! Mine has been acting like that lately but only when the truck is cold. Once it warms up it's fine. I have some extra wire here from an audio build I'm about to do. It darn sure can't hurt to try this.
My question is...where did you hear about this and what was someone doing to think they should ground the TB in the first place?
It's actually a "trick" that started for better throttle response at the track when TBs started to be "fly-by-wire" and not using a traditional, manual throttle cable anymore.
There are some HUGE threads on other forums about this and I believe a pretty active discussion on the Diablo Tuner forum as well. There is a thread about it on this forum in the 4th Gen section.
The throttle motor is grounded but only with the tiny wire in the harness, but the actual throttle body is not and is connected to the manifold by a rubber boot, so no grounding. I measured impedance on my TB that fluctuated between 1.86 and 2.28 Ohms with my meter and then simply touched the grounding cable to it and chassis ground and watched it peg to zero.
The theory on better throttle response centers around electrical noise (think of an aftermarket stereo that's not grounded well and whines when you accelerate - same principle here).
Some have not seen any benefit, but most have seen at the very least a steadier idle. As I stated, my erratic idle is smooth as **** now and I am getting slightly better throttle response, but I'm fairly highly modded. Some guys with stock trucks who have done this are reporting a day/night difference in throttle response and even transmission shifts.
Best thing about this is it's virtually a free mod and even if it doesn't do a thing for you, it can't hurt anything. You're simply hooking up an extra ground wire.