03 1500 5.7 Hemi misfire

[Mkrogh14]

When getting off the Highway truck started running like crap. Was about 5 mins from the house. When I got home hooked up the obt 2 and said “Random/Multiple Cylinder Misfire P0300. I pulled and changed all the plugs. Truck seems to be running on like 2 cylinders. I pulled the coils 1 by 1 and had spark on the coil but no cylinder fire. Checked fuel pressure on the rail and it’s at 48psi. Was wondering if anyone had this issue before. I went and unplugged all the coil packs 1 by 1 to see if the motor would sound different but I had 1-5 unplugged and it was still running the same once I unplugged coil 6 the truck stalled so that’s how I found out I was having nothing from 1-5

 

[Martins hemi]

My guess
Intake gasket

 

[Dodge 1500 4X4]

Do a compression test on cylinder that has the misfire a low reading will tell you if a cam/lifter is in your future, you could also have an injector 1or2 clogged, put some Seafoam in your gas tank and see if it runs better be patient, how many miles?