^ Yes... Rotating Mass, and Rolling Resistance will be a factor in going with a WIDE 33'' tire. Its no different then going with a 35'' really. My factory tires were ( Wrangler HP's ) weighing in at 43 lbs each. Now the standard tire has changed to the Wrangler SR-A's...
275/60/20 - Goodyear Wrangler SR-A's = 40 lbs. Per Tire ( 33x10.8" )
305/55/20 - Goodyear Duratrac's = 62 lbs. Per Tire ( 33x12.5" )
22 lbs of additional weight per corner is gonna create extra work for the engine / transmission, and will also have a noticeable difference in steering feel. Your going to notice a drop in MPG no matter what. Now you can slightly help offset the the weight of a heavier tire, by going with a lighter weight rim. I chose **** Cepek DC-2's because I liked the look, but after I bought them I realized that they are a bit lighter then the oem 20x9 chrome clads. The clads weigh roughly 38 lbs each I believe. My DC-2's are 31.6 lbs each. Roughly 6.5 lbs lighter per corner. If we owned auto cross cars that would be huge savings, but we own trucks lol. It's nit picking alittle, but to some people it counts.
I wanted to go with a 305/55/20 tire awhile back, but I didnt want to tank my gas any more then is lol, and now im driving alot more highway to my new job. So I ended up going with 275/60/20 Nitto Terra Grapplers. They give my truck an aggressive look, and I like the new steering feel. The big selling point is the tire weight. They weigh 43 lbs each, same as my original Wrangler HP's.
Even sticking with the OEM tire size, you can still find heavier tires that will drop your MPG. The New BFG A/T KO2's weigh in at 59 lbs each !!!!! for a stock size tire ! Take into consideration Load Range as well.