Not necessarily. Pushing the engine hard with a tune that advances timing and alters air/fuel ratio to increase cylinder pressure(torque) will a lot of times bring out issues that you would probably not see in normal operation when the ignition system is not being pushed so hard. I had similar issues in past vehicles and had to eventually change to colder spark plugs because the tune would run the spark plug hotter than what it was designed for and it developed hairline fractures like in the picture below. When pushed hard, this caused some of the energy used for a spark to seep through the insulation causing misfires.
This is why I always say check the spark plug when you have a code like that, and are running a tune that alters timing and air/fuel rations to increase cylinder pressures(torque). You may have to increase/decrease the gap or get colder plugs that can handle the heat and keep up with the tune just like the old racers did back in the day when they increased power.
Spark Plugs: Fact and Fiction