Some of them actually do exactly what they say they do, generally it takes a lot longer then they say. And it depends on what you are trying to do. If your main concern is the combustion chamber, nothing will work as good and fast as sea foam. If you want to clean injectors, PEA cleaners are above all else IMO. Redline S1 and Amsoil fuel treatment have the largest % of PEA, some gumouts have a good % but you need to read the msds to see which ones, and also techron the original PEA cleaner. Look at the youtubes out there where a guy drops a boroscope and runs tests. If you really want clean injectors and chamber, you probably have to use them every tank, and think about it that will add 5 dollars to every single tank if you use Redline S1. Running them once or twice takes away slim in the chamber, that slime usually becomes varnish. Commit to it, either run them or choose not to. The good ones like S1 also have a heavy upper cylinder lube, some people think this helps with the drying effect of ethanol, although I haven't seen scientific info on this. Do your own research, look up PEA fuel treatments and see what this stuff does. I would bet the guys saying they don't do ****, never ran their own tests.