Depends on how it's built and who's tuning it. Mine was very reliable for the 30k out of 50k I had it supercharged. I even towed my travel trailer with it. Just don't go crazy with the boost on a stock bottom end. Too many people want all the power, without spending the money to make all the power without blowing it up.
Tuning is really the #1 factor in doing it right. Find a shop that can do it right, spend the money, it's not cheap. But knowing your boost levels, AFR throughout the RPM range, temps, pressures and timing are spot on goes a long way towards reliability.
But, yeah, probably not best suited as a daily driver. If I was going to daily the truck I'd have spent the extra money on rods and pistons. Didn't stop me from towing my bass boat all over NC, SC, VA and TN, or going to shows all over as well.