I run E85 most of the time, in my area it runs between .60 and .90 cents cheaper on average. Based on that price difference it generally saves me about 10 to 20 percent on fuel cost. The 3.6 does put out more HP on E85. One way I can tell is if I floor it off the light on E85 it is on the traction control and pulling the throttle all the way to 60. If I turn traction control off I get a bit of wheelspin on each gear shift. Don't get that on E10. So I did a couple of acceleration times and 0-60 on E10 I was getting 8.1 and on E85 7.5. Keep in mind I have 3.55 gear and Tradesman QC trim so my truck is lighter than average. Where E85 shines is on towing, recent trip got 7.9 on E85 and 8.9 on E10. Difference was .25 cents per mile on E85 and .32 on E10.
Seems like there is a lot of misinformation floating around on the E85. My guess is if E85 were priced competitively outside the Midwest people would be more open to buying it. In my case for day to day driving the price difference needs to be 20% to break even. I filled up today and E10 was 2.279 so break even for E85 would be 1.829. I got e85 at 1.629. I used the GasBuddy app to find the best prices.