This is a bank one issue. Here could Be some causes.
Intake Manifold leak at a specific cylinder.
Fuel Injector problem.
Variable cam lift failure.
Camshaft/valvetrain problems.
Ignition system problems a specific cylinder.
Engine mechanical problems relating to cylinder combustion at a specific cylinder.
The cylinder imbalance detected requires that the Upstream O2 sensors are capable of operating at high frequencies, since an aged O2 sensors response capability at a higher frequency range can be degraded. Therefore, before this minitor come become active, the O2 sensor high frequency response monitor is performed to see if the sensor is even capable of detecting in imbalance.
Once active, the cylinder imbalance detection monitor matches up the upstream O2 sensor signal with the coressponding cylinder on the bank. Each cylinder is monitored and adjusments are made as needed for each cylinder to correct an air/fuel ratio imbalance. If an individual cylinder reaches a calibrated adaption threshold 15%), the diagnostic monitor will be considered failing.
Personally I'd look at spark plugs if they Havnt been done recently and maybe go from there.