This is true. But how do you tune for a fuel that may be different each time you fill up? The amount of timing you could safely add would vary with what was in the tank.
Flex fuel ready vehicles have alcohol sensors and built in timing tables to use depending on the alcohol mix, my 2010 Silverado crew cab 5.3L is Flex fuel ready, i can pump whatever gas i want with any alcohol content in it, and i don't need to worry about tuning for it.
You can also use a WB to tune for it if there is no sensor, but you have to adjust your PCM stoich ratio to a value that matches the stoich present in the fuel, correct your airflow model if you had mods, then fuel trims will do the rest providing you're not going from e85 to e15 on the next tank, this will work,
https://www.amazon.com/Quick-Fuel-Technology-36-E85-Sample/dp/B007ZJ749O
You have to account for timing, you have to account for other little things in the tune, you have to have enough injectors, and depending on mods, a fuel pump capable of providing enough fuel at WOT, the rest is intenet BS. i ran e85 in a 09 Pontiac G8GT for a couple of years as a daily driver, that car had enough injectors from the factory to run the gas, and never ever had an issues with it, i used e85 to turn up the timing on the cheap side, i had long tubes and a healty camshaft, 100 octane gas is about $9-$11 a gallon over here, e85 is a tad more expensinve than the POS 91 octane we get in Socal, sometimes is cheaper too. Alcohol burns cleaner than gas, you just need to tune for it if your calibration is not ready for it. e85 is good stuff if you want to crank some more power, ask the Supercharged/turbocharged folks about e85, way different of course if you want to win hypermilling competitions with it. e85 is not for everybody.