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OP is asking about a 5th gen. What works for your 4th gen may not necessarily work on a 5th gen.I have that size, LT275/65R20 on my stock wheels, (2013) with no issues whatsoever.
Currently have the stock/Night edition 275/55R20's with all-seasons. Looking to get a snow-tire but keep the current wheels. Any issue with going to a 275/65/20 size, for example?

I've used that same size tire on 3 stock/un-lifted 1500s in the past and my current 2" lifted Ram 1500 with no "real" issues to worry about.Currently have the stock/Night edition 275/55R20's with all-seasons. Looking to get a snow-tire but keep the current wheels. Any issue with going to a 275/65/20 size, for example?
Also, if you get a much heavier tire, your acceleration may suffer some, especially from stopped.
This is a good example of when the gears in the rear end make a big difference.
lol, Hemi’s rock!The acceleration with my 3.21 Hemi and 10-ply E-rated BFGs weighing in at just under 53 pounds each, isn't lacking, AFAIC.
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lol, Hemi’s rock!
Put the same diameter tire that weighs 43 pounds, and you will see a big difference!
I have a 3.21 myself, but if I was going to run big mudders, I’d have gotten the 3.92. I like the mileage on the highway too much.
Enjoy the nice tires.
I had a pedal commander for my last truck. They do spice things up!I use 40-pound Michelin Defenders as summer tires every year. There may be a minuscule difference with the 'get up and go', but nothing too noticeable.
Ever since installing the Pedal Commander, the truck always feels like a rocket ship to me.
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Also, if you get a much heavier tire, your acceleration may suffer some, especially from stopped.
This is a good example of when the gears in the rear end make a big difference.
Put the same diameter tire that weighs 43 pounds, and you will see a big difference!
I have a 3.21 myself, but if I was going to run big mudders, I’d have gotten the 3.92. I like the mileage on the highway too much.

No. I had a 2011 4.7 and put larger diameter and heavier Lt tires on it. Different transmission but made it downright dangerous turning with traffic coming. Terrible acceleration, especially 1st and second gear.Have you actually confirmed this theory by doing some acceleration tests using the different sized/weights of tires with some certifiable type of device (like a GPS/G-force based type of track data instrument)?
"Seat of the pants" data doesn't count because IF there is any acceleration differences using what amounts to being "slightly heavier tires", the differences will be miniscule to say the least.
TALLER (or shorter) tires DO have an affect of changing the final drive ratio of the vehicle, but honestly, the "tire weight" differential itself has very little to do with any observed change in the vehicle's rate of acceleration (within reason of course; don't get silly and say you're going to use 400# tires compared to 40# ones).
By your logic then, heavier tires "should" get you better mileage on the highway too (assuming the heavier tire is the same diameter as the lighter ones OR the truck's ECU has been properly flashed to accommodate the larger tire diameter with the fewer rotations per mile they will make).
Certainly, the heavier tire would have more rotational inertia to keep the truck rolling along, once they have reached the desired highway speed, right? Harder to start rolling means harder to stop rolling too, right? Thus, better mileage on the highway!
I think you are overlooking the change of final drive ratio which comes from the use of larger diameter (and usually slightly heavier) tires and confusing it as being an affect which is accounted for by tire weight alone.