Thanks for all the input. After looking at some new 5th wheels today, the height of these new trucks is definitely an issue. If we end up getting one, I don't see 37's going under the truck. 35's might be a stretch without lifting the trailer a bunch.
However, I ran a test running around the 200 mile drive today, keeping the truck in 5th gear, which with the 33's and 3.73 ratio, according to my calculations, put my rpms about where 4.88's would be in 6th until I go bigger. It amazes me how well the 6.4 runs when it is hovering on both sides of 2k rpm running 60-75 mph. MPG's were within 1 of my best to date.
Can only imagine what these would do without having to push a button to make the truck act the way it should to begin with. Really want to feel real gearing in the rest of the power band on this truck. Coming from the 1500 with the 3.0 diesel, 3.92 gearing and that smooth 8 speed, there is a lot of room for improvement.