Maybe I'm too long in the tooth, but I change @ 50,000 miles. Why? Because my past experience with platinum coated plugs advertised to be "100,000 mile" plugs was they were worn / eroded / pitted / deposits by then.
Now we have iridium coated, which are some % higher resistance to pitting and wear. But there are still 16 of the things so rather than leave them in and wait until I have a problem with misfire and sputtering, I still plan to change these at 50,000 miles. Maybe I'm nuts, so be it.
And I'm not replacing with OE "laser" iridium, either. Those have iridium coating on BOTH electrodes, but the later Hemi's don't use dual polarity waste spark ignition. That's the only time you need both electrodes coated. I'm going with the significantly less pricey NGK Iridium IX - which only coats the positive electrode. Because that's all that's needed.