Empty and at moderate speeds is where our MDS equipped 6.4 shine through. The old V10s and GM 8.1 would likely be better towing motors equipped with a 6 speed. Their power came on at lower RPM.
Towing, MPG is probably within 1-2 mpg across the board from chevy 6.0 through 8.1 and all displacement truck motors between. Stop and go traffic, towing or and 80+ mph and MDS is not kicking in as much if at all.
For a 2500 gasser I was pleasantly surprised coming from 2 ecoboost F150. I didn't believe the 20+ hype with the EB so I wasn't disappointed. It still got 2-3 mpg better hwy than my 5.4l F150 did, about the same in town. The 6.4l will beat the numbers my 5.4l did on the highway by 1-2mpg, around town it's 1-2 less. Better all around than the wife's old Mountaineer. I don't know if it was her driving or the vehicle, but that thing would manage 13.8 highway when she'd drive anywhere.
For me it seems 72mph is a threshold. After that mileage falls off quickly.
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