You'll want to adjust the WDH with the truck and trailer fully loaded. The best way is adjust them is by using a CAT scale to weigh the truck and trailer together, then drop the trailer and weigh just the truck.
The 6700 is probably the GVWR of the trailer which sounds a little heavy for a 4K dry trailer. The GCVWR of the truck and trailer is going to about 14K lbs.
Use the Tow/Haul mode and let the transmission do its things. The torque peak of the Hemi is 4K RPMs, it's normal for the engine to need to rev higher while towing. Run 89 octane fuel, but 8-10 mpg fuel economy numbers are likely..
Keep in mind that at 100 km/h you'll be covering the length of a football field every three seconds. It takes approximately 1 second to realize what's happening and another second to actually react to the situation. It takes about about half a football field to stop just the truck traveling at 100 km/h, that length can double to triple easily while towing.