The only DEF crystallization would be in the DEF tank at the pickup tube. This occurs when DEF sits and it crystallizes around the tube inlet. These trucks are made to pull and be under a load. Sitting parked and only an occasional grocery run will not use very much DEF.
DEF usage is Post Ignition, it's in the exhaust system. DEF is sprayed into the exhaust causing it to "Stick" to the DPF (Diesel Particulate Filter) grids. As the DPF grids fill with the unburnt exhaust pollutants, there are two pressure sensors, one forward the DPF and one aft. When these two sensors tell the computer that there is a pressure difference, it will trigger a Regeneration. Meaning raw diesel fuel is sprayed into the DPF causing it to "Super Heat" burning the pollutants into harmless ash and blowing it out the exhaust pipe.
DEF is not connected to the Check Engine Light, it has it's own light in our trucks. The message is, "Service DEF System, See Dealer". This means No DEF is following. It could be out, clogged or the pump has quit working. Either way, this will throw the truck into a mileage countdown. (I think it's 150 miles.) At the end of the countdown, the truck will go into limp mode. (5 MPH max. speed)
If you get the warning, pull the DEF tank and clean the pickup tube. If the pump is bad, the Aftermarket folks are making replacements. OEM is or was $1200.
It's not really a complicated system but it is a very expensive system. That coupled with EGR restrictions is why lots of folks delete their trucks.