I put Firestone transforce Es on a 2000 ford expedition Eddie bauer's and it helped towing a lot.
They are heavy tires though so be prepared for a fuel mileage hit. Yes you will feel more road imperfections, but that didn't bother me, personally. I aired mine up to 70 psi when towing and 80 a few times with no issues with no I'll effects.
If you two a lot they are a worthwhile upgrade.
If you like your truck to feel like your driving a 70s Cadillac as 1/2 tons come from the factory, you might not like E tires. If you expect a truck to ride and feel like a truck, then they likely won't bother you.
Good luck in your decision