They are saying at your truck max load capacity thay 49psi should work great for you, well thats how I read it.
I would set them at 45psi empty and 50psi loaded and go from there.
^^ That's exactly what they are saying
When I had my 2014 1500 4x4 with 295/60r20s I ran 45 psi front & 40 psi rear. That worked great for me both as an unloaded daily driver and even when loading up for camping trips and 4 adults + 2 kids. The rear end sag looked more concerning than the slight tire bulge. That was 2 -3 days dry camping. I'd estimate about 700# of gear and about 700# in the cab.
For the 2500 4x4 I'm in now, I run 52/48 in 37x12.50r20 E Nitto Trail Grapplers. With 55 psi in the rears and a yard of topsoil, I had next to NO tire bulge. So I lowered my psi. I will probably lower the rears to 45 after winter is over.
As a side note, when I had my Jeep JK, I ran 30 psi all around, and she was a pig of a rig! Steel front & rear bumpers, full size spare, winch, Front D44 trussed, full steel skid plates (engine, trans, gas tank, & evap). Rock sliders too, but they don't really count since they were aluminum. Tires were 35x12.50r17 toyo AT2s and chalk test empty had the sweet spot at 28, but I just kept them at 30.