I also have the issue on my 2019 1500 Big Horn Crew 4x4. I also have a customer with a 2019 Laramie also with same issue. In Texas, we always have wind. I have found that folding the power mirrors in helps some but is it just me and this is a 2019 issue? When the wind is over 20 mph, it just howls. Can't turn the radio up any louder to drown it out. If someone has the magic cure, please let me know.
I have only 11k but did change the cabin air filter with no difference. Also tonneau cover did not help.
I put weatherstrip around top 8" and front 12" of door. It broke resonance of the wind. The air is getting in the front and top of door trying to push it out. Put a piece of anything in their and it will quiet the noise. If the wind can't get in, it can't pull on the door. I used an old original piece of door seal from a 1950 ford coupe because it was on my bench. Bad design.
2019 BH Crew, 3.6, Michelin LTX, electric bed cover, no sun roof, Level 2 package.