I had 4.10s done sept '14, and haven't shut up about them, since.
AZ, I am a firm believer that the Old Wives Tale about tall gearing equalling better fuel economy is a load of crap, and a hold over from the old days when vehicles had 3 and 4 speed transmissions. And I think it's that preseption, that makes Dodge put those stupid tall gears in their trucks. They sell what people want, not what is correct. I remember telling guys that I was having 4.10s put in the truck, and they'd say: What are you going to do, go drag racing?!
I've gone down 2 steps when gearing the Ram, and it's still taller than the factory gears in the 13 V6 Mustang, or the 14 Jeep Wranler.
I haven't lost any potential fuel economy. My last tank, of my version of mixed driving, got 16.98 mpg. I've gotten 20, when I've gone 55-65. Now, in practical application, it's hard not to step on it more, because the truck is so much more responsive and fun.
The only down side to 4.10s is the initial cost, which is a BARGAIN!
Go for it!