In the end it's basically a wash with both having the same final drive ratio's,but on the one hand the 3.92's in 7th are easier on u-joints /driveshaft etc., but on the other hand the 3.21's operating in 6th is easier on the transmission.The strongest gear in a transmission is always the straight through direct drive gear,whether it's an automatic or a manual transmission.I guess you could pick your poison,do you want to abuse the u-joints more,or do you want to abuse the transmission more,the u-joints are definitely cheaper and easier to replace then the transmission,lol
I'd also say we can rule out the motor mounts as being a weak link in a Ram,they've been proven to handle in excess of 1100 rwhp