I find that with my 2011 5.7, I get the best mileage (and thus range) at 65mph. If I push it to 70 I don't lose much. Using cruise control can go either way in terms of mileage depending on your geographical location. I have very light hills here, nothing too major by any means and it's best to gradually throttle up with losing a bit of speed knowing you'll regain the speed - and then some - going down the hill. Cruise control in this case will burn more fuel by often downshifting a gear depending on the grade, let along maintaining a set engine speed when it's not always necessary. Setting my cruise above 65mph just means I play in traffic more, instead of letting everyone pass and waste their fuel.
Speed generates heat as well, in bearings, etc, which adds drag on top of the heavy wind resistance already set. I'm not sure what the parameters of the MDS system is, but after getting more than 600kms a tank in split city/highway driving from just watching my throttle position and driving habits makes all the difference. I notice a drop in mileage when I select gears manually. It's hard to keep the HEMI 'on boil' even with 3.55 gears in the city as 35mph in second gear is only around 2500rpm, well below the torque peak of the engine.
I believe in the first gen 5.7's the MDS would only be effective up to a certain speed, and it was increased in the latest programming for the 2009+ trucks.