The way the system is designed in the new trucks integrates the HU for a lot of functions. And it is hard to remove and even harder to add aftermarket equipment.
The issues you will encounter with the Premium System are as follows:
1. The system uses a CanBus signal between the HU and the amp. That means when you turn the volume knob, the signal from the HU to the amp doesn't change; rather a signal goes over the CanBus to the amp telling it to increase volume. If you are planning to add aftermarket equipment you will not be able to get full frequency signal from between the HU and AMP. The signal is fixed and does not increase or decrease with the volume knob. No one has come up with module yet to capture the HU signal and CanBus data.
2. There are no full signal speakers in the truck. There appears to be a crossover built in to the amp; so you get mids from the door and tweets from the dash. The rear doors appear to be close to full signal; but, to prevent customers from blowing speakers; anything below about 50hz is attenuated. (That's my guess; some folks have done RTA graphs and there appears to be a big fall off around 50hz.)
3. The Premium System has 2ohm speakers on the end. So, if you get the Premium System and decide to "upgrade" the speakers; if you get 4 ohm speakers (most common) you will see a decrease in volume. Many users report changing the speakers and having good results; but, depending on what you are going for; just be aware of the load change.
4. Removing the factory HU will require getting the truck flashed since the CanBus will be missing the factory HU. I suppose if you don't mind replacing the head you can go this route; but, I didn't want to lose the factory HU and my build will have to address the problems I just mentioned; plus the ones I haven't found yet.
I am not familiar with "non premium" system characteristics; but, if you are planning on "upgrading" the premium system; plan on getting your wallet out and doing a full install that includes a DSP that will rebuild a flat full signal and then going out to amps etc.