I do a 1-2x weekly commute of 100 miles round-trip to the office (I work from home the rest of the week), and the nearest grocery store to my house is a 20-mile drive. I live on a small hobby farm in the Oregon Coastal Range, and the heaviest things I'll likely ever tow would be a 24' camper or a 2-horse trailer (both around 3500 lbs or so gross-weight). The bed often has a full load of firewood in it. I have a v6, and it works just fine for what I need. Most days I drive it empty though, hauling or towing about once a week (-ish).
Truck specs are in my profile - 2017 QC 4x4 SLT, 3.6 engine w/ 3.21 gear ratio. About as low-end as you can possibly go, powertrain-wise, but it does everything I want it to do w/o complaint.
I average 24-25mpg unladen, since nearly all of my driving is at highway speeds. Towing drops it to maybe 18-20mpg, depending.
I bought the truck in mid-June, and have put around 5,000 miles on it since then. I figure I'll average 10-11k miles per year on it. The whole time I've had it, I think I drove my wife's Kia Soul exactly once for a quick nip into town to pick up a few things.
HTH a little.