I tow a 2017 Jayco Eagle 324bhts TT not a fifth wheel that is listed at 8900 dry from factory according to yellow sticker. So i would expect it is close to 10k loaded for camping. My 6.4 with 4.10s seems to be averaging 8.5 mpg. Not great but not horrible. I have heard of people actually gain mpg going to a 5er but dont ask me how. I would like to switch to 4.56 gears soon. For now I am going to just try and tow in 4th gear and keep it there to see if mpgs drop or stay same. This will put it close to what 4.56 will give me rpm wise but not the mechanical advantage the better gears would have. With 4.56 gears i could run 5th at what 4th will give me now.
I don't know if your running 33's or 35's for tires, but all this gear talk lately got me diving into some rpm #'s this past weekend. I'm running 4.10's with the 33's (275/70R18) stock size. I used a RPM calculator off of one of the gear sites I looked at. I too thought going down a gear at hwy speeds would be like 4.56's, when in fact, its more like a 4.88's . Here's a little table I put together.
4th Gear, RPM's
R&P 60mph 65mph 70mph
4.10 2505 2713 2922
4.56 2786 3018 3250
4.88 2981 3230 3478
5thGear, RPM's
R&P 60mph 65mph 70mph
4.10 2054 2225 2396
4.56 2284 2475 2665
4.88 2445 2648 2852
6thGear, RPM's
R&P 60mph 65mph 70mph
4.10 1553 1682 1812
4.56 1727 1871 2015
4.88 1848 2002 2156
As you can see, having a 4.10 already and dropping a gear at hwy speeds is more closely to a 4.88 than a 4.56 especially going from 5th to 4th gears.
(I.E. 65 mph w/4.88 in 5th = 65 mph in 4th w/ 4.10)
I don't have any qualms with the 4.10's at hwy speeds with the loads I pull as I can easily manage the gearing with the +/- button. However, what gets me is the low speed range 20-40 mph on our county roads that have progressively steeper grades on the hills and 2nd gear doesn't cut it and when it asks for 1st its difficult not to slam into it. I just got quoted $2700 for gears from my local shop.....which, is hard to swallow, and for that amount of money, I just may look for a used CTD tradesman of the same year as my truck.....IDK...