I've never had a 5th wheel, but have been researching them recently. As mentioned above the boxes are probably over some of the frame/mounting points for the under bed 5th prep wheel framing. Another thing that I would be concerned about is, that I have seen that people have clearance issues for the pinbox (I think that is the term) clearing the bed side when making hard turns. With the bed side being even closer on a rambox, you might have a real problem.
I watched some videos about sliding hitches and people doing 90 deg maneuvers... you could see where the hitch/framing on the 5th wheel can come in contact with the bed side.